EBD Blog

I guess one can read geneses as a typographical variant on genes or, as I intended, as the plural of genesis. Using it the latter way: Emerging evidence makes it appear even more unlikely than ever that researchers will be able to identify a relative few genes—let alone the or one gene—for schizophrenia. Writing under the headline “Gene-Hunters Find Hope and Hurdles in Schizophrenia Studies,” the noted science journalist Nicholas Wade published an article summarizing research that points to the conclusion that there may be many different genetic bases for schizophrenia.

Two groups of researchers hunting for schizophrenia genes on a larger scale than ever before have found new genetic variants that point toward a different understanding of the disease.
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The variants discovered by the two groups, one led by Dr. Kari Stefansson of Decode Genetics in Iceland and the other by Dr. Pamela Sklar of the Massachusetts General Hospital, are all rare. They substantially increase the risk of schizophrenia in those affected but account for a tiny fraction of the total number of cases.

This finding, coupled with the general lack of success so far in finding common variants for schizophrenia, raises the possibility that the genetic component of the disease is due to a very large number of variants, each of which is very rare, rather than to a handful of common variants.

This is an article well worth reading. Link to Mr. Wade’s arctile.