Archive for the 'News' Category

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New review of early intervention in Autism from Pediatrics

Zachary Warren and colleagues from Vanderbilt University published a review of 34 studies of early intervention efforts with children who have Autism in Pediatrics in April of 2011. The authors interpret their results as providing tempered supported for the the early intervention methods often described as “UCLA,” “Lovaas–based,” “EIBI,” or the “Early Start Denver Model.” Here is the abstract.

A Systematic Review of Early Intensive Intervention for Autism Spectrum Disorders
by
Zachary Warren, Melissa L. McPheeters, Nila Sathe, Jennifer H. Foss-Feig, Allison Glasser and Jeremy Veenstra-VanderWeele

CONTEXT: Early intensive behavioral and developmental interventions for young children with autism spectrum disorders (ASDs) may enhance developmental outcomes.

OBJECTIVE: To systematically review evidence regarding such interventions for children aged 12 and younger with ASDs.

METHODS: We searched Medline, PsycINFO, and ERIC (Education Resources Information Center) from 2000 to May 2010. Two reviewers independently assessed studies against predetermined inclusion/ exclusion criteria. Two reviewers independently extracted data regarding participant and intervention characteristics, assessment techniques, and outcomes and assigned overall quality and strength-of evidence ratings using predetermined criteria.

RESULTS: Thirty-four unique studies met inclusion criteria. Seventeen studies were case series; 2 were randomized controlled trials. We rated 1 study as good quality, 10 as fair quality, and 23 as poor quality. The strength of the evidence overall ranged from insufficient to low. Studies of University of California Los Angeles/Lovaas–based interventions and variants reported clinically significant gains in language and cognitive skills in some children, as did 1 randomized controlled trial of an early intensive developmental intervention approach (the Early Start Denver Model). Specific parent-training approaches yielded gains in short-term language function and some challenging behaviors. Data suggest that subgroups of children displayed more prominent gains across studies, but participant characteristics associated with greater gains are not well understood.

CONCLUSIONS: Studies of Lovaas-based approaches and early intensive behavioral intervention variants and the Early Start Denver Model resulted in some improvements in cognitive performance, language skills, and adaptive behavior skills in some young children with ASDs, although the literature is limited by methodologic concerns.

Warren, Z., McPheeters, M. L., Sathe, N., Foss-Feig, J. H., Glasser, A., & Veenstra-VaderWeele, J. (2011). A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics, 127, e1303–e1311. Published online Apr 4, 2011; DOI: 10.1542/peds.2011-0426

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Secretin still does not help

Shanthi Krishnaswami and colleagues examined the research about the effects of using secretin as a theraputic agent for the treatment of Autism. They found that there were none of the seven randomized controlled trials showed beneficial effects and, therefore, concluded that secretin does not merit consideration as a therapy. Their finding, which employs rigorous methods, is consistent with earlier analyses that examined more preliminary research and which I have reported previously (as far back as the 1990s).

A Systematic Review of Secretin for Children With Autism Spectrum Disorders
by
Shanthi Krishnaswami, Melissa L. McPheeters and Jeremy Veenstra-VanderWeele

CONTEXT: As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Secretin is 1 of many medical treatments studied for treating the symptoms of ASDs, but there is currently no consensus regarding which interventions are most effective.

OBJECTIVE: To systematically review evidence regarding the use of secretin in children with ASDs who are aged 12 years and younger.

METHODS: We searched the Medline, PsycINFO, and ERIC (Education Resources Information Center) databases from 2000 to May 2010 and reference lists of included articles. Two reviewers independently assessed each study against predetermined inclusion/exclusion criteria. Two reviewers independently extracted data regarding participant and intervention characteristics, assessment techniques, and outcomes and assigned overall quality and strength-of-evidence ratings on the basis of predetermined criteria.

RESULTS: Evidence from 7 randomized controlled trials supports a lack of effectiveness of secretin for the treatment of ASD symptoms including language and communication impairment, symptom severity, and cognitive and social skill deficits. No studies have resulted in significantly greater improvements in measures of language, cognition, or autistic symptoms when compared with placebo; study authors who reported improvement over time did so equally for both the intervention and placebo groups.

CONCLUSIONS: Secretin has been studied extensively in multiple randomized controlled trials, and there is clear evidence that it lacks benefit. The studies of secretin included in this review uniformly point to a lack of significant impact of secretin in the treatment of ASD symptoms. Given the high strength of evidence for a lack of effectiveness, secretin as a treatment approach for ASDs warrants no further study.

Krishnaswami, S., McPHeeters, M. L., & Veenstra-VanderWeele, J. (2011). A systematic review of secretin for children with autism spectrum disorders. Pediatrics, 127, 1322-1325. DOI 10.1542/peds.2011-0428

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Autism awareness

World Autism Awareness Day is upon us. Check on it!

While you’re thinking about the topic, learn a lot by watching Fred Volkmar’s presentation about interventions for Autism: “Treatments for Autism: Overview of Model Programs.”

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Altering Autism insurance coverage legislation in VA

Writing in the Richmond Times Dispatch, Olympia Meola reported on potential changes in support for insurance coverage for therapy for children with Autism in the Commonwealth of Virginia in the US. Under the headline “McDonnell will try to amend autism bill,” Ms. Meola described developments in Governor Robert “Bob” McDonnell’s plans for altering recent legislation requiring insurance payments for treatment.

Gov. Bob McDonnell is expected today to reveal proposed changes to a bill requiring insurance coverage of autism treatments, and some could be substantial alterations to what the General Assembly passed.

Conversations were continuing as of Tuesday between the governor’s office, lawmakers and interested parties about possible changes to a measure that would require coverage of autistic children ages 2 to 6.

Advocates of the bill said some significant tweaks could be “deal breakers.”

The amendments floated in the past week range in scope, from technical to more substantial, including changes in who could supervise treatment and when the law would take effect, according to those familiar with the proposals.

Link to Ms. Meola’s story.

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ASAT newsletter’s available

For those readers interested in Autism who do not already subscribe to the newsletter of the Association for Science in Autism (ASAT), I have a nourishing treat: The latest issue of Science in Autism Treatment (SIAT) is now available. You can learn about ASAT and SIAT by going to the ASAT homepage and scouting about the many valuable resources there, including learning about and subscribing to the SIAT newsletter. Subscribe and you won’t have to depend on my flaky reminder system to let you know when one arrives in my mailbox!

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Follow up of Fast Track

These are the lead researchers in the Conduct Problems Prevention Research Group with their current universities (over the years, some have changed affiliations):

The Conduct Problems Prevention Research Group, a team of composed of seven of the most eminent US scholars studying the development of childhood behavior disorders, published another in its series of papers tracking the outcomes of the children it has been following in a long-term study about preventing acting out disorders. In this longer-term follow-up analysis, the team found that the effects were still present for the children who showed the most risk of having behavior disorders in the first place.

This project and these folks are the big time. The work has been conducted very carefully and cannot be represented as an example of over-hyped findings.
Continue reading ‘Follow up of Fast Track’

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Autism legislation in Virginia

Under the headline “Autism legislation advances in Virginia” in the Washington Post Fredrick Kunkle and Anita Kumar reported about the slow-but-significant progress that parents in the US state of Virginia have made in advancing toward mandating coverage of treatment for Autism by insurance companies. That the advances run counter to many conservative US legislators’ opposition to health policies that mandate coverage for those in need of services and that it is occuring in an election year in Virginia, a state that usually tilts toward the conservative, makes the analysis especially intriguing.

In the beginning, several Northern Virginia families whose children have autism thought that their wrenching stories would be enough to get some help from their representatives in the General Assembly.
Continue reading ‘Autism legislation in Virginia’

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CCBD conference 2011

The Council for Children with Behavioral Disorders (CCBD) is hosting a meeting at the Sheraton Norfolk Waterside Hotel in Norfolk (VA, US) and the registration deadline is tomorrow, 3 February 2011. CCBD has reduced the fees and there are spcial discounted rates for teams of three or more attendees.
Continue reading ‘CCBD conference 2011′

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NAS presses MH pubs

Noting recent news in the US, the National Academy of Sciences has taken the opportunity to promote some of its publications related to mental health. Among these is one that is relevant to those concerned about EBD among children and youths, a 2009 report by the Institute of Medicine and National Research Council that I’ve mentioned previously, Preventing Mental, Emotional, and Behavioral Disorders Among Young People. Here’s the full release:

Mental Health Care Gains Attention in Wake of Tucson Shooting

By Christine Stencel

January 21, 2011 – The attack on U.S. Rep. Gabrielle Giffords and her audience in Tucson, Ariz., has touched off a national discussion about the capabilities of the country’s mental health system. The majority of respondents to a USA Today-Gallup Poll survey said failure of the mental health system bears “a great deal” of the blame for the Tucson shooting. Two reports from the Institute of Medicine and National Research Council provide guidance on improving mental health care in the United States.

Preventing Mental, Emotional, and Behavioral Disorders Among Young People, a 2009 report by the Institute of Medicine and National Research Council, calls for national leadership in the prevention of these disorders and promotion of young people’s mental health. Many preventive programs and strategies have been shown to be effective, the report notes, but the country lacks priorities and public goals for these efforts. The report outlines steps that federal and state agencies, community groups, and parents can take to intervene when symptoms arise and to promote mental health.

Improving the Quality of Health Care for Mental and Substance-Use Conditions, an earlier report from the Institute of Medicine, underscored the need for greater parity for care of mental conditions and substance abuse in the nation’s health care system. The separation of mental health from other forms of medical care undermines the overall quality of Americans’ well-being, it says. The report outlines an agenda to capitalize on recent advances in diagnosing and treating these conditions and better integrate them into the health care delivery system.

Link to the NAS Web site for appropriate links to the documents.

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The Congressional Mental Health Caucus

Sadly, mental health has been in the US news of late. I’m reminded that in the US legislature there is the Congressional Mental Health Caucus, which takes as its goals reducing negativism and stigma, aiding efforts to access mental health services, improving work-related productivity, and protecting veterans who have mental health problems. Although the caucus does not explicitly state child mental health as a focus of concern, it has supported awareness efforts such as National Children’s Mental Health Day.
Continue reading ‘The Congressional Mental Health Caucus’

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Deer’s fraud case in BMJ

Brian Deer, the journalist who has doggedly pursued the story about a link between materials in vaccines and the onset of childhood Autism proposed by Dr. Andrew Wakefield and colleagues in the late 1990s, has published details explaining why he considers the original research establishing that link to have been fraudulent. In the first of a series of articles appearing in the prestigious British Medical Journal, Mr. Deer reports the results of his efforts to locate and interview the originally anonymous parents of the children included in the study by Dr. Wakefield et al.—which was published in the Lancet and then retracted—and it is sure to generate lots of heat, and perhaps a little bit of light.
Continue reading ‘Deer’s fraud case in BMJ’

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More props for Mr. Artest

Professional basketball player Ron Artest, who admits that he experienced difficulties as a youth and an adult, has been promoting mental health awareness over the past few years. Recently I posted a note acknowledging some of his efforts, and today I call attention to another of them. At the release of the accompanying public service announcement 21 December 2010 in support of mental health awareness, Mr. Artest not only spoke in support of those efforts, but he also donated $50,000 to local clinics in the Los Angeles (CA, US) area.

In a blog post for the Los Angeles Times entitled “Ron Artest debuts his PSA on mental health awareness,” Mark Medina reported about the press conference and the production of the PSA. If you’re a Lakers fan, as am I, you’ll find a couple of tidbits of interest there. But, there are also noteworthy nuggets about mental health advocacy and even about the entertainment industry in Mr Medina’s report, too. He has an audio interview with Gary Foster, who produced the video (as well as the noted movie “The Soloist,” also about mental health), and additional notes about Mr. Artest’s efforts.

According to Mr. Medina, on Christmas Day, another of Mr. Artest’s fund- and awareness-raising efforts on behalf of mental health will be in the spotlight. The ring that Mr. Artest received as a member of the world championship Los Angeles Lakers team of 2010 will be awarded to the winner of a raffle. That raffle has reportedly raised over $500,000 US. (I bought my raffle tickets, of course.)

As a fan of the Lakers for 50 years, I’m glad Mr. Artest is playing for my team, but I’m especially happy to have him on the mental-health advocacy team. My hat’s off to you, Mr. Artest.

Read all of Mr. Medina’s entry, Ron Artest debuts his PSA on mental health awareness. Check my earlier post from 11 November 2010.

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