EBD Blog

Janie Shelton and colleagues at the University of Califonia at Davis reported that women over 40 years of age who give birth have an increased risk of the child having Autism. By studying a large sample of births, the researchers were able to disentangle the relative contributions of maternal and paternal age to the likelihood of having a child with Autism.

This study conflicts with some previous research that pointed at paternal age as a factor in Autism (see the EBD Blog page by Leslie Feldman on Fathers’ Age as Contributor to Risk for Autism). The Shelton et al. analysis expressly examined the relative contributions and points at maternal age as an independent factor. Additional research will help to clarify the relationships.
Continue reading ‘Maternal age increases risk of Autistic offspring’

As most readers probably know, the UK General Medical Council censured Dr. Andrew Wakefield for his research that supposedly shows a link between immunization with the measles-mumps-rubella (MMR) vaccine and autism. The Autism corner of the blogosphere has been rife with discussion (more than what I can up with keep). However, Liz Ditz has been maintaining a catalog of notes pro and con regarding the finding. For those who are interested, read Andrew Wakefield: Dishonesty, Misleading Conduct, and Serious Professional Misconduct: Blog Posts Critical of Verdict; Blog Posts Approving of Verdict

Also see theBBC news coverage, MMR scare doctor ‘acted unethically’ panel finds, and the UK Telegraph story, “GMC brands Dr Andrew Wakefield ‘dishonest, irresponsible and callous’.”

I want to note that readers should understand that the GMC investigation, though very important, did not expressly examine the scientific basis of Dr. Wakefield’s case. The findings discuss whether he was qualified to do the work and followed procedures in seeking approval for it. The scientific strength of the findings from the study in question have been examined extensively by well-qualified researchers and found wanting, though (see, for example, Hornig et al., 2008).

Buie et al.’s “Take-Away Messages”

In Pediatrics Dr. Timothy Buie and colleagues published a paper providing evidence-based recommendations for pediatricians who evaluate and treat gastrointestinal problems in patients with Autism. The authors, who represent many important scientific groups concerned with allergies, gastrointestinal disorders, nutrition, and similar problems, concluded that children with Autism and related disorders should be assessed and, as approriate, given medical care just as would individuals without Autism. The team encouraged pediatricians to develop and employ “evidence-based algorithms for the assessment of abdominal pain, constipation, chronic diarrhea, and gastroesophageal reflux disease (GERD).”
Continue reading ‘Science, gastro-intestinal problems, diets, and Autism’

Writing in Molecular Psychiatry, L. Palmieri of the Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco-Biology, University of Bari (Bari, IT) and colleagues reported the results of a small-n study of levels of metabolic transporters in the brain tissue of individuals with and without Autism. They compared the contents of samples from the brains of individuals with Autism and individual without Autism (matched on the bases of sex, age, and time after death that the samples were obtained). They found aspartate-glutamate carrier activity was increased by excessive calcium levels in brains of the Autistic individuals.
Continue reading ‘Excessive levels of calcium mark brains of individuals with Autism’

Right here in my home commonwealth of Virginia last week, Mira Signe, Vicki Hardy-Murrell, John Morgan, and Margaret Nimmo Crowe explained why it is important that government and private organizations attend to and address issues in children’s mental health. By explaining that Virginia has inadequate services and that one in every five children or youths experience mental health problems at some time during their lives, they made the point that that there is a tremendous need for public focus on these issues. This was the kick-off event for the Campaign for Children’s Mental Health.

The Campaign for Children’s Mental Health is a 3-year sustained effort to make mental health services more available and accessible to Virginia children in need. It will strongly endorse Governor-elect McDonnell’s call for system improvements; urge the General Assembly and state and local government to work collaboratively with the administration to address system deficiencies; and conduct a high-profile three-year advocacy and education drive to build public and political support for improved mental health services for children.

Only about one in 20 of Virginia’s children have access to the key services listed in the accompanying box. So, four out of five children who need these services do not have access to them.

No, Virginia, this is not an acceptable way to treat our children. Let’s do better.

• Down load the press release (source of the excerpt quoted here).
• Read coverage in these newspapers:
  • Lynchburg News and Advance—Coalition pushes mental-health care for children
  • Washington Examiner&mdash:Advocates start bid to expand children’s mental health services under bleak budget;
  • Richmond Times Dispatch— Coalition advocate mental-health care for children
  • Washington Post (blog)—New coalition has AG’s support for mental health reforms
• Visit (and support) the Web site of the Campaign for Children’s Mental Health.
• Download pdfs of “Survey of Community Services Board Child and Adolescent Services” and “Review of Community Services Board Child and Adolescent Services“; these are report by James W. Stewart, Inspector General for Virginia’s Mental Health, Mental Retardation & Substance Abuse Services (now called Behavioral Health and Development Services). The list of key services comes from these reports;
• Visit the < href="http://www.facebook.com/pages/The-Campaign-for-Childrens-Mental-Health/183467424796?v=wall" target="_blank">Facebook page;
• Listen to a brief (3+ min) interview with Ms. Crowe from WMRA: Pushing for Children’s Mental Health Reform.

In a letter to Nature, Lauren Weiss, Dan Arking, the Gene Discovery Project of Johns Hopkins, and the Autism Consortium report that they have analyzed multiple data sets and identified potential loci on human genes for susceptibility for Autism. They found possible linkages on four chromosomes (5p15, 6q27, and 20p13) and, coupled with other data, the single nucleotide polymorphism on 5p15 pointed to SEMA5A as an important location for additional study. These results may lead to a means of screening; if rare variations can be identified reliably, they would permit families to seek intervention very early in the lives of affected individuals, thus greatly increasing the chances of improved outcomes.

Although autism is a highly heritable neurodevelopmental disorder, attempts to identify specific susceptibility genes have thus far met with limited success1. Genome-wide association studies using half a million or more markers, particularly those with very large sample sizes achieved through meta-analysis, have shown great success in mapping genes for other complex genetic traits. Consequently, we initiated a linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms (SNPs) in a common set of 1,031 multiplex autism families (1,553 affected offspring). We identified regions of suggestive and significant linkage on chromosomes 6q27 and 20p13, respectively. Initial analysis did not yield genome-wide significant associations; however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 10-7). We also demonstrated that expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene. The linkage regions reported here provide targets for rare variation screening whereas the discovery of a single novel association demonstrates the action of common variants.

Link to the abstract.

In Scientific American, Daniel Lametti wrote an article providing background research on mirror neurons and implications for future research. The article, “Mirroring Behavior: How mirror neurons let us interact with others,” only has a few words about Autism and mirror neurons. However, readers of EBD Blog who are new to the topic and who want to understand the concepts in general will likely benefit from reading it.

Link to Mr. Lametti’s article.

The US National Academies Press announced the publication of a book entitled Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities that discusses prevention of problems during childhood, adolescence, and young adulthood. Edited by Mary Ellen O’Connell, Thomas Boat, and Kenneth E. Warner, the book represents the work of the Board on Children, Youth and Families. It is available in hardback, as a PDF, or online (the last option is free).

Mental health and substance use disorders among children, youth, and young adults are major threats to the health and well-being of younger populations which often carryover into adulthood. The costs of treatment for mental health and addictive disorders, which create an enormous burden on the affected individuals, their families, and society, have stimulated increasing interest in prevention practices that can impede the onset or reduce the severity of the disorders.

Prevention practices have emerged in a variety of settings, including programs for selected at-risk populations (such as children and youth in the child welfare system), school-based interventions, interventions in primary care settings, and community services designed to address a broad array of mental health needs and populations.

Preventing Mental, Emotional, and Behavioral Disorders Among Young People updates a 1994 Institute of Medicine book, Reducing Risks for Mental Disorders, focusing special attention on the research base and program experience with younger populations that have emerged since that time.

Researchers, such as those involved in prevention science, mental health, education, substance abuse, juvenile justice, health, child and youth development, as well as policy makers involved in state and local mental health, substance abuse, welfare, education, and justice will depend on this updated information on the status of research and suggested directions for the field of mental health and prevention of disorders.

Link to the press release or the ordering page.

Under the title “The Father Factor: How Dad’s Age Increases Baby’s Risk of Mental Illness: Could becoming a father after age 40 raise the risks that your children will have a mental illness?” in Scientific American, Paul Raeburn reported on the association of paternal age with childhood schizophrenia and Autism. Using the birth of his own child as a springboard, Mr. Raeburn recounts some of the research on this topic. For example, he covers Dolores Malaspina’s epidemiological work as well as mouse-analog studies by Jay Gingrich. It’s a good introduction to the topic.

Read Mr. Raeburn’s article. Also, for additional resources, please see Leslie Feldman’s “Fathers’ Age as Contributor to Risk for Autism” from right here on EBD Blog.
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Last month when I first saw the title “Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink,” I was initially skeptical, but I wanted to check what was being proposed, so I jumped right past the author list and read the abstract. I was a bit intrigued, thinking to myself, “Hmmm…maybe there’s more to this than I thought.” Then, when I went to locate the actual article, I realized that the second and third authors were the Geiers, David and Mark. Slowed by the connection, I put the study aside for later review. Now, others have already done the analysis for me, and those analyses are the focus of this entry.
Continue reading ‘Young et al. deconstructed’

Nope, not an experiment about how to get kids to clean their rooms, but a proposal to study the effects of a hypoallergenic environment on the behavior of children with Autism. According to an article by Timothy McNulty entitled “Doctor plans novel treatment for autism,” that’s the idea. Writing in the 11 May 2008 issue of the Pittsburgh (PA, US) Post-Gazette, Mr. McNulty reported that a physician named Scott Faber in the Pittsburgh area plans to create an environment that will be free of toxins and examine the effects of living in such an environment on children with Autism.
Continue reading ‘Clean room study’

According to Liz Ditz of I Speak of Dreams, Stephen Hinshaw gave the closing keynote speech at the Learning and the Brain conference in San Fransisco (CA , US). Professor Hinshaw, who chairs the Department of Psychology at the University of California—Berkeley and is an eminent psychologist with a list of accolades as long as my arm, spoke about his current book on the stigma associated with mental illness. Liz’s report starts as follows:

The closing keynote speech at the San Francisco Learning and the Brain conference was by Stephen P. Hinshaw on The Mark of Shame: Attitudes Toward Mental Illness (With Emphasis on Children). I thought it was excellent. You should read his memoir of his father’s life-long struggle with mental illness, The Years of Silence are Past: My Father’s Life with Bipolar Disorder. An interview is here; the Amazon link is here.

Continue reading ‘Hinshaw about mental illness’