Tag Archive for 'evidence'

Denny Reid in C’ville!

Dennis Reid, a renowned researcher and clinician who for more than 35 years has worked with individuals who have Autism, will speak on 22 September 2011 on “Evidence-Based Strategies for Promoting Enjoyment among People with Autism” in Charlottesville (VA, US). The talk by Mr. Reid, which is free and open to the public (but registration is required), is part of the Virginia Institute of Autism (VIA) Autism Speaker Series and is sponsored by VIA and the University of Virginia Children’s Hospital. It is scheduled for 5:30-6:30 at St. Anne’s-Belfield Greenway Rise Campus, Randolph Hall Auditorium. To register, go to VIA’s Web site viaschool.org or call (434) 923-8252.

For those who are unfamiliar with Mr. Reid’s research, he has an extensive record of work in behavior analysis, having published repeatedly in the Journal of Applied Behavior Analysis. He’s based at the Carolina Behavior Analysis and Support Center in Mogantown (NC, US) which, oddly, doesn’t seem to have a Web site.

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Research participation opportunities

In an accompanying PDF I have listed studies that are currently seeking children (both female and male) with Emotional of Behavioral Disorders (especially autism spectrum disorders) as participants (some include adults, as well) that are registered with ClinicalTrials.gov, a service of the US National Institutes of Health (NIH). The studies have diverse purposes: They may be observing different events (whether overt behavior or neurochemical activity) or they may be testing different therapies (ranging from behavioral to medical methods). Many are sponsored at least in part by the NIH, but some have funding from universities or even private industries. Because of its affiliation with NIH, ClincialTrials.gov is more likely to represent medically oriented studies and studies that use rigorous scientific methods (i.e., randomized clinical trials or RCTs), but this is not exclusively the case. Readers should examine the studies carefully.

The list is not exhaustive (I used “autism” in the search, so there are many more studies that could be located by using other terms), and I’ve provided only some of the data about each study in the table, but you can learn a fair bit about individual studies. For example, one can learn about study number NCT00198107 that is entitled “Evaluating the Effectiveness of Aripiprazole and D-Cycloserine to Treat Symptoms Associated With Autism.” It focuses on individuals with Autistic Disorders and examines an intervention (in this case, comparing drugs called Aripiprazole D-cycloserine to placebo in a randomized design with double-blind (Subject, Caregiver, Investigator, Outcomes Assessor) | Primary Purpose: procedures. The study began 1-Sep-05 and will end 1-Sep-11 (making it odd that it is still listed as open, no?).

To locate additional information about a particular study, copy the NCT ID number, go to ClinicalTrials.gov, and enter that number into the search box. Download the PDF here (10 pages).

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Cog mod for PTSD

In the Journal of Behavior Therapy and Experimental Psychiatry, Joanna Kowalik and colleagues reported that their review of studies on the use of cognitivie behavioral therapy for treating posttraumatic stress disorder (PTSD) revealed that cog-mod appears effective in changing raters’ responses on some of the widely used scales of the Child Behavior Checklist. However, the results of their literature review are not as powerful as one might hope, given the small number of studies and substantial variability in the studies themselves.

Abstract

Background and objectives There is no clear gold standard treatment for childhood posttraumatic stress disorder (PTSD). An annotated bibliography and meta-analysis were used to examine the efficacy of cognitive behavioral therapy (CBT) in the treatment of pediatric PTSD as measured by outcome data from the Child Behavior Checklist (CBCL).

Method A literature search produced 21 studies; of these, 10 utilized the CBCL but only eight were both 1) randomized; and 2) reported pre- and post-intervention scores.

Results The annotated bibliography revealed efficacy in general of CBT for pediatric PTSD. Using four indices of the CBCL, the meta-analysis identified statistically significant effect sizes for three of the four scales: Total Problems (TP; ?.327; p = .003), Internalizing (INT; ?.314; p = .001), and Externalizing (EXT; ?.192; p = .040). The results for TP and INT were reliable as indicated by the fail-safe N and rank correlation tests. The effect size for the Total Competence (TCOMP; ?.054; p = .620) index did not reach statistical significance.

Limitations Limitations included methodological inconsistencies across studies and lack of a randomized control group design, yielding few studies for meta-analysis.

Conclusions The efficacy of CBT in the treatment of pediatric PTSD was supported by the annotated bibliography and meta-analysis, contributing to best practices data. CBT addressed internalizing signs and symptoms (as measured by the CBCL) such as anxiety and depression more robustly than it did externalizing symptoms such as aggression and rule-breaking behavior, consistent with its purpose as a therapeutic intervention.

Because they are integrating so few studies it is very difficult to have a sensitive meta-analysis in this case. However, that Professor Kowalik and her collaborators found differences at all is encouraging. I hope they’ll continue to follow this literature. Also, I hope researchers will be using other measures of outcomes and that those other measures will be examined in future integrative literature reviews, too.

Kowalik, J., Weller, J., Venter, J., & Drachman, D. (2011). Cognitive behavioral therapy for the treatment of pediatric posttraumatic stress disorder: A review and meta-analysis. Journal of Behavior Therapy and Experimental Psychiatry, 42, 405-413. doi:10.1016/j.jbtep.2011.02.002

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ASAT newsletter’s available

For those readers interested in Autism who do not already subscribe to the newsletter of the Association for Science in Autism (ASAT), I have a nourishing treat: The latest issue of Science in Autism Treatment (SIAT) is now available. You can learn about ASAT and SIAT by going to the ASAT homepage and scouting about the many valuable resources there, including learning about and subscribing to the SIAT newsletter. Subscribe and you won’t have to depend on my flaky reminder system to let you know when one arrives in my mailbox!

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Follow up of Fast Track

These are the lead researchers in the Conduct Problems Prevention Research Group with their current universities (over the years, some have changed affiliations):

The Conduct Problems Prevention Research Group, a team of composed of seven of the most eminent US scholars studying the development of childhood behavior disorders, published another in its series of papers tracking the outcomes of the children it has been following in a long-term study about preventing acting out disorders. In this longer-term follow-up analysis, the team found that the effects were still present for the children who showed the most risk of having behavior disorders in the first place.

This project and these folks are the big time. The work has been conducted very carefully and cannot be represented as an example of over-hyped findings.
Continue reading ‘Follow up of Fast Track’

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Deer’s fraud case in BMJ

Brian Deer, the journalist who has doggedly pursued the story about a link between materials in vaccines and the onset of childhood Autism proposed by Dr. Andrew Wakefield and colleagues in the late 1990s, has published details explaining why he considers the original research establishing that link to have been fraudulent. In the first of a series of articles appearing in the prestigious British Medical Journal, Mr. Deer reports the results of his efforts to locate and interview the originally anonymous parents of the children included in the study by Dr. Wakefield et al.—which was published in the Lancet and then retracted—and it is sure to generate lots of heat, and perhaps a little bit of light.
Continue reading ‘Deer’s fraud case in BMJ’

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Sugar’s still not to blame

The sugar-makes-kids-hyper hypothesis is still false. Dan Willingham stuck another fork in it. Roasty-toasty. All done. Fizzle.

Now, I’m not advocating a high-fructose, feed-’em-soda-and-sweets diet, to be sure. It’s just that folks need to disabuse themselves of the popular myth that children’s levels of behavioral activity are governed by consumption of sucrose (whether from sugar cane or sugar beet).

Professor Willingham, who pops bubbles with the best of them, lanced this one in his guest post, “The Answer Sheet: How sugar really affects kids.” The evidence is basically the same as what I covered in the mid 1990s under the title “Sugar High?.”

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WWC on Lovaas model

The US Department of Education’s What Works Clearinghouse (WWC) released the results of its review of the model for teaching children with Autism that is based on the work of the late Ivar Lovaas on 24 August 2010. The WWC report is based on two of the many studies of the Lovaas method—often called “Applied Behavior Analysis”—and reports positive results for cognitive outcomes.
Continue reading ‘WWC on Lovaas model’

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ASAT newsletter available

Those who subscribe to it know that the summer issue of Science in Autism Treatment, the newsletter for the Association for Science in Autism Treatment (ASAT), arrived today in their electronic mailboxes. For folks who are interested in Autism but who do not subscribe, here’s a catalog of content in this issue.
Continue reading ‘ASAT newsletter available’

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Brain features associated with neonatal risk for schizophrenia

Differences in neonate brains

Writing in the American Journal of Psychiatry, John Gilmore and colleages reported that the size and structure of the brains of newborn boys—but not girls—who are at risk for developing schizophrenia differ from those of their peers. Using multiple scanning methods at different times during gestation and infancy, the researchers compared the brains of offspring of mothers who have schizophrenia to the offspring of mothers who do not have schizophrenia; they found that high-risk boys had larger brains and larger lateral ventricles than baby boys whose mothers did not have psychiatric illness.

Because the risk of developing schizophrenia is much greater for close relatives of schizophrenics, the differences between the groups provides a strong indicator of later potential development of disease. Professor Gilmore wondered “Could it be that enlargement is an early marker of a brain that’s going to be different?”
Continue reading ‘Brain features associated with neonatal risk for schizophrenia’

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CNV and Autism

Over on Science Based Medicine, David Gorsky has an extended post explaining the finding reported in “Functional Impact of Global Rare Copy Number Variation in Autism Spectrum Disorders” by Dalila Pinto and colleagues (and there are ship load of colleagues) that appeared in Nature. Dr. Pinto and colleagues examined copy number variations (CNVs; deletions, insertions, duplications, and other differences in genetic structure that have been a hot topic in genetics since ~2007) that are associated with Autism. Dr. Gorsky’s summary is well worth the read, saving me the task of summarizing this important report.

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ASAT Online

AST Online’s most recent newsletter (as of this date) provides lots of helpful information. Check it!




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