Brian Deer, the journalist who has doggedly pursued the story about a link between materials in vaccines and the onset of childhood Autism proposed by Dr. Andrew Wakefield and colleagues in the late 1990s, has published details explaining why he considers the original research establishing that link to have been fraudulent. In the first of a series of articles appearing in the prestigious British Medical Journal, Mr. Deer reports the results of his efforts to locate and interview the originally anonymous parents of the children included in the study by Dr. Wakefield et al.—which was published in the Lancet and then retracted—and it is sure to generate lots of heat, and perhaps a little bit of light.
Continue reading ‘Deer’s fraud case in BMJ’
Tag Archive for 'Research'
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The sugar-makes-kids-hyper hypothesis is still false. Dan Willingham stuck another fork in it. Roasty-toasty. All done. Fizzle.
Now, I’m not advocating a high-fructose, feed-’em-soda-and-sweets diet, to be sure. It’s just that folks need to disabuse themselves of the popular myth that children’s levels of behavioral activity are governed by consumption of sucrose (whether from sugar cane or sugar beet).
Professor Willingham, who pops bubbles with the best of them, lanced this one in his guest post, “The Answer Sheet: How sugar really affects kids.” The evidence is basically the same as what I covered in the mid 1990s under the title “Sugar High?.”
Sphere: Related ContentThe US Department of Education’s What Works Clearinghouse (WWC) released the results of its review of the model for teaching children with Autism that is based on the work of the late Ivar Lovaas on 24 August 2010. The WWC report is based on two of the many studies of the Lovaas method—often called “Applied Behavior Analysis”—and reports positive results for cognitive outcomes.
Continue reading ‘WWC on Lovaas model’
Those who subscribe to it know that the summer issue of Science in Autism Treatment, the newsletter for the Association for Science in Autism Treatment (ASAT), arrived today in their electronic mailboxes. For folks who are interested in Autism but who do not subscribe, here’s a catalog of content in this issue.
Continue reading ‘ASAT newsletter available’
Writing in the American Journal of Psychiatry, John Gilmore and colleages reported that the size and structure of the brains of newborn boys—but not girls—who are at risk for developing schizophrenia differ from those of their peers. Using multiple scanning methods at different times during gestation and infancy, the researchers compared the brains of offspring of mothers who have schizophrenia to the offspring of mothers who do not have schizophrenia; they found that high-risk boys had larger brains and larger lateral ventricles than baby boys whose mothers did not have psychiatric illness.
Because the risk of developing schizophrenia is much greater for close relatives of schizophrenics, the differences between the groups provides a strong indicator of later potential development of disease. Professor Gilmore wondered “Could it be that enlargement is an early marker of a brain that’s going to be different?”
Continue reading ‘Brain features associated with neonatal risk for schizophrenia’
The U.S. Food and Drug Administration (FDA) issued a warning letter to the producer of a product that is sometimes used by people hoping to eliminate heavy metals from children’s bodies (e.g., chelate mercury from children with autism). In a letter addressed to Boyd D. Haley of CTI Science Inc., Teresa C. Thompson of the Cincinnati District Office of the FDA cited a host of problems in the classification and marketing of the product, OSR#1. Among these problems are the following:
Continue reading ‘FDA warns seller of chelation product’
Over on Science Based Medicine, David Gorsky has an extended post explaining the finding reported in “Functional Impact of Global Rare Copy Number Variation in Autism Spectrum Disorders” by Dalila Pinto and colleagues (and there are ship load of colleagues) that appeared in Nature. Dr. Pinto and colleagues examined copy number variations (CNVs; deletions, insertions, duplications, and other differences in genetic structure that have been a hot topic in genetics since ~2007) that are associated with Autism. Dr. Gorsky’s summary is well worth the read, saving me the task of summarizing this important report.
Sphere: Related ContentIn an editorial under the headline “Bad science gets its due,” the editors of the Boston (MA) Globe lament the consequences of Andrew Wakefield’s promotion of a connection between vaccines and Autism. At the end of the piece, the editorialist makes an important point:
But sadder still is the possibility that, in the minds of thousands of parents desperately clinging to hopes of finding a cure for autism, Wakefield’s legend might survive untarnished, possibly even exalted. In reality, his work on autism offers an unfortunate example of poor research trumping the scientific method.
Too bad the writer overlooked some of the other consequences. Here are a few nominees for a list repercussions:
Continue reading ‘Bad science?’
The publishers of Nature are promoting a new site, Scitable. The publishers bill Scitable as “a free science library and personal learning tool brought to you by Nature Publishing Group, the world’s leading publisher of science. Scitable currently concentrates on genetics, the study of evolution, variation, and the rich complexity of living organisms.” Autism is one of the topics featured at Scitable, so I’ll be reviewing what’s there and monitoring for updates about the scientific study of Autism at it’s “Spotlight on Autism.”
Sphere: Related ContentOver on Countering Age of Autism, Kim Wombles has an extended post about research on facilitated communication. She’s not just gathered together the evidence that is familiar to those who have followed the science, but also engaged in discussion in the comments section of the post. Take a look at Facilitated Communication: A Review of the Literature. While you’re there, check many of her other sensible and clear posts.
Sphere: Related Content
In “A Prospective Study of the Emergence of Early Behavioral Signs of Autism,” Professor Sally Oznoff and colleagues found that infants who develop Autism behave differently than their typically developing peers even as early as one year of age. Writing in the Journal of the American Academy of Child & Adolescent Psychiatry, the researchers reported about a comparison of video tapes of children (n=50, half of whom had Autism) made at six-month intervals during infancy and early childhood.
Continue reading ‘Autism appears early’
Janie Shelton and colleagues at the University of Califonia at Davis reported that women over 40 years of age who give birth have an increased risk of the child having Autism. By studying a large sample of births, the researchers were able to disentangle the relative contributions of maternal and paternal age to the likelihood of having a child with Autism.
This study conflicts with some previous research that pointed at paternal age as a factor in Autism (see the EBD Blog page by Leslie Feldman on Fathers’ Age as Contributor to Risk for Autism). The Shelton et al. analysis expressly examined the relative contributions and points at maternal age as an independent factor. Additional research will help to clarify the relationships.
Continue reading ‘Maternal age increases risk of Autistic offspring’
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